Nitrazepam continues to be connected with extreme hepatic Issues, similar to other nitrobenzodiazepines. Nitrobenzodiazepines such as nitrazepam, nimetazepam, flunitrazepam, and clonazepam are more harmful to your liver than other benzodiazepines as These are metabolically activated by CYP3A4 which may end up in cytotoxicity.Tolerance to nitrazepam